Unlocking the Longevity Code for Your Brain and Body
What is the APOE Gene?
The APOE gene (Apolipoprotein E) helps your body move fats and cholesterol through your
bloodstream. Everyone has two copies—one from each parent—and they come in three
variants: E2, E3, and E4.
- E3 is the most common.
- E2 may actually be protective against Alzheimer’s and cardiovascular disease.
- E4, though? That’s where things get interesting.
If you carry one or two copies of APOE4, research shows you may have:
- A higher risk for Alzheimer’s disease and cognitive decline
- Slower detoxification capacity (especially of environmental toxins and metals)
- More inflammation and plaque build-up in the brain and body
- Faster tissue repair and scar tissue formation—which isn’t always a bad thing
The Double-Edged Sword of APOE4
From an evolutionary perspective, APOE4 had advantages.
Signs You Might Be Feeling the Effects
You don’t need a genetic test to notice possible APOE4-related issues. Common symptoms
include:
- Brain fog or memory problems, especially under stress
- Poor response to high-fat or high-carb diets
- Trouble detoxing after mold, Lyme, heavy metals, or alcohol
- Heightened anxiety or sensitivity to inflammation
- A strong family history of dementia, cardiovascular issues, or autoimmune disorders
What You Can Do About It (APOE4 is Not Your Destiny)
Here’s the good news: Genes load the gun, but environment pulls the trigger. Your lifestyle
choices can dramatically reduce your risk and optimize your brain health—especially if you
know what to focus on.
At Axon Integrative Health, our approach to supporting APOE4 carriers includes:
Brain-Optimized Lifestyle
- HIIT + Strength Training to boost BDNF and mitochondrial function
- Sleep hygiene protocols to clear brain waste via glymphatic drainage
- Targeted brain stimulation and neurofeedback to improve cognitive resilience
Smart Nutrition
- Low-inflammatory, nutrient-dense diets (think Mediterranean meets wild Paleo)
- Avoiding trans fats and processed carbs
- Cycling healthy fats like olive oil, omega-3s, and MCT—but watching saturated fat in
E4s
Evidence-Based Supplementation
- Citicoline – supports memory, attention, and neuroplasticity
- Phosphatidylcholine (PC) – essential for cell membrane and liver detox
- Omega-3s (DHA/EPA) – brain fuel and inflammation modulator E4s
- Curcumin, resveratrol, and NAC – to support detox pathways and reduce oxidative stress
Functional Therapies for Longevity
- IV Therapy for cellular energy and detox support
- HBOT to enhance oxygen delivery and cognitive clarity
- PEMF + Red Light Therapy to improve tissue healing and brain regeneration
- qEEG + NeuroIntegration to track and improve functional brain health over time
stress
Knowledge is Power
Knowing your APOE status is a powerful piece of your personal health map. But you don’t need to live in fear of your genes. With the right tools, strategies, and support, you can thrive—with clarity, vitality, and a long, strong life ahead.
Want to find out how your brain is aging—and what you can do about it?
Schedule a discovery call or ask about our Brain Longevity Program at Axon Integrative
Health. We’re here to help you biohack your way to better brain health—gene or no gene.
