Exploring the Neurometabolic Cascade Following Concussion: Unveiling Physical, Metabolic, and Psychological Components

Concussions in Denver: The complex background cascade of excitotoxicity after the hit.


Concussions, often referred to as mild traumatic brain injuries (mTBIs), are more than just a bump on the head. They trigger a complex series of events within the brain known as the neurometabolic cascade. At Axon Integrative Health, we are committed to shedding light on the intricate interplay of physical, metabolic, and psychological components that follow a concussion. Join us as we delve into the depths of this cascade to better understand the multifaceted nature of concussions and their effects on the brain.

The Physical Component: Unmasking the Neuroinflammatory Response of Concussions

Following a concussion, the brain undergoes a rapid sequence of physical changes. One of the most critical components is the neuroinflammatory response. This immune response involves the release of cytokines, small proteins that regulate immune cell communication. While inflammation is a natural defense mechanism, excessive and prolonged inflammation can be detrimental to brain health. It can also lead to a glutamate (the excitatory neurotransmitter of the brain) toxicity referred to excitotoxicity, making your brain run in the “redline” consistently leading to fatigue, brain fog, headaches, and other concussion symptoms.

At Axon Integrative Health, we emphasize a holistic approach to managing the physical aftermath of concussions. Our team of specialists understands the importance of addressing inflammation through personalized treatment plans that include rest, proper nutrition, and targeted neurorehab therapies. By addressing the physical component of the neurometabolic cascade, we aim to support the brain’s healing process and minimize long-term complications.

The Metabolic Component: Energy Crisis and Mitochondrial Dysfunction of Concussions

Concussions disrupt the brain’s delicate energy balance, leading to a metabolic crisis. This crisis is primarily driven by mitochondrial dysfunction, where the powerhouses of our cells struggle to produce sufficient energy for normal brain function. As a result, neurons become vulnerable and more susceptible to further damage.

At Axon Integrative Health, we recognize the significance of metabolic support in concussion recovery. Our approach involves tailored nutritional, and IV strategies that provide the brain with the necessary nutrients to facilitate energy production and support mitochondrial health. By addressing the metabolic aspect of concussions, we aim to enhance the brain’s resilience and promote optimal recovery.

The Psychological Component: Unraveling the Emotional Toll of Concussions

Beyond the physical and metabolic changes, concussions often exert a profound psychological impact. Mood swings, anxiety, depression, and cognitive challenges can all emerge as a result of the neurometabolic cascade. These psychological changes are intertwined with the physical and metabolic aspects, creating a complex web of symptoms that require comprehensive care.

At Axon Integrative Health, we prioritize the psychological well-being of our patients. Our team of experts understands the interconnected nature of these components and works diligently to offer integrative treatments that encompass cognitive therapies, neurofeedback therapy, neuromodulation, mindfulness practices, and emotional support. By addressing the psychological component of concussions, we aim to restore a sense of balance and enhance overall quality of life.


The neurometabolic cascade following a concussion underscores the intricate relationship between physical, metabolic, and psychological components. At Axon Integrative Health in Denver, we are dedicated to providing comprehensive care that addresses each facet of this cascade. Through personalized treatment plans, encompassing physical therapies, metabolic support, and psychological interventions, we strive to guide our patients towards a holistic recovery journey. If you or a loved one are seeking expert care for concussion management, contact us today to embark on a path towards optimal healing and well-being.

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